Abstract: Thymidine Phosphorylase (TP) is a kind of peptide growth factor which has a closelation with tumor angiogenesis. In recent years, it has attracted more attention about inducing tumor growth, predicting patients' survival and the efficacy of chemotherapy. TP promotes tumor growth and metastasis by increasing the intratumoral microvessel density in tumor stroma. The expression of TP is correlated significantly with the tumor recurrence and metastasis. The use of Capecitabine has been proved that TP can increase the Thymidine antitumor effect of fluorouracil derivatives.